Silver nanoparticles (AgNPs) exhibit pH-responding affinity for doxorubicin, but challenges remain in their aqueous-mediated stabilisation and synthesis-related toxicity. This study investigated a green synthesis of AgNPs for its optimisation, followed by a preliminary screen for their doxorubicin-loading capability. The optimal procedure includes biocompatible reagents only, i.e.: AgNO₃ (precursor), D-glucose (reductant), starch (stabiliser), and aq. NaOH (pH adjuster), coupled with an ultrasonic bathing (42 kHz; 100 W) and room temperature (25 °C). The starch-matrix AgNPs were successfully synthesised and characterised by UV-Vis spectroscopy (λ_a 400 nm; I_a 3.0-3.5 abs., D ̅_(size(UV-Vis)) 20-45 nm), XRD (2θ = 38.1° (111), 44.3° (200), 64.4° (220), 77.4° (311); JCPDS 04-0783; D ̅_(size(XRD)) ca. 15 nm), SEM (AgNPs-starch morphology; D ̅_(size(SEM)) 10-30 nm), EDX (C: 0.285 keV; O: 0.525 keV; Na: 1.044 keV; Ag: ~3 keV), and FT-IR (no evidence of functional changes). The nanoparticles demonstrate their ability for pH-responsive doxorubicin loading and release, confirmed by UV-Vis analysis. The results encourage efforts for more in-depth understanding and further in-practice testing.